Mercy comments on Should I be afraid of GMOs? - Less Wrong
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How exactly would pesticide resistant genes transfer to weeds? Unless the your GMO plant interbreeds with weeds, witch is not very likely based on the fact that you do not often stumble upon tomato-dandelions (if I'm terribly misinformed here please tell me). And horizontal gene transfer, have not been observed to any large extent in multicellular organisms.
Sorry I missed this reply before, note sure if it's worth replying but briefly yes, narrow-band pesticides take care of the most distantly related weeds so your biggest problems are "volunteers" from the previous crop rotation, and wild relatives of whatever crops you are planting. That's why you have to modify the crop, rather than the pesticide.