My thinking of late is that if you embrace rationality as your raison d'etre, you almost inevitably conclude that human beings must be exterminated. This extermination is sometimes given a progressive spin by calling it "transhumanism" or "the Singularity", but that doesn't fundamentally change its nature.

To dismiss so many aspects of our humanity as "biases" is to dismiss humanity itself. The genius of irrationality is that it doesn't get lost in these genocidal cul-de-sacs nor in the strange loops of Godelian undecidability in trying to derive a value system from first principles (I have no idea what this sentence means). Civilizations based on the irrational revelations of prophets have proven themselves to be more successful and appealing over a longer period of time than any rationalist society to date. As we speak, the vast majority of humans being born are not adopting, and never will adopt, a rational belief system in place of religion. Rationalists are quite literally a dying breed. This leads me to conclude that the rationalist optimism of post-Enlightenment civilization was a historical accident and a brief bubble, and that we'll be returning to our primordial state of irrationality going forward.

It's fun to fantasize about transcending the human condition via science and technology, but I'm skeptical in the extreme that such a thing will happen -- at least in a way that is not repugnant to most current value systems.