In addition to the emotional issues you raise, there's the question of thresholds and scalability. If the puppy program already exists, giving $10 will help more puppies. But, for many scientific research projects, there's no point in even starting with less than $100K in hand. That could be $10 each from 10,000 people. An easy decision, perhaps, for the 9999th person, but who wants to give the first $10?

Elsewhere I've suggested "Social Escrow" as a solution. You pledge a certain amount, contingent on enough other people doing so and perhaps on other objective criteria. "Send us two checks. We'll tear up both if not enough other people send checks. We'll tear up the second if the research doesn't meet kilometerstone X by date Y."

Kickstarter has some of these features, but doesn't seem to fund science.