Is their meaningful data on thalamic stimulators with erodic side-effects? (See entry #1 here: http://www.cracked.com/blog/5-disturbing-ways-the-human-body-will-evolve-in-the-future/ ). Cracked gives the addictive potential of an accidental orgasm switch plenty of attention while citing just two examples (it's a comedy site after all), but have other cases been studied? I'm not convinced this couldn't be done intentionally with current models of the brain.