I would. I'd want to do some shorter test runs first though, to get used to the idea, and I'd want to be sure I was in a good mood for the main reset point.
It would probably be good to find a candidate who was enlightened in the buddhist sense, not only because they'd be generally calmer and more stable, but specifically because enlightenment involves confronting the incoherent naïve concept of self and understanding the nature of impermanence. From the enlightened perspective, the peculiar topology of the resetting subjective experience would not be a source of anxiety.
Toy model of an upload-based AI that doesn't seem to suffer too many of the usual flaws:
Find an ethical smart scientist (a Gandhi-Einstein), upload them, and then run them at ultra high speed, with the mission of taking over the world/bringing friendliness to it. Every hour of subjective time, they get reset to their initial specifications. They can pass any information to their resetted version (limiting the format of that info to a virtual book or library, rather than anything more complicated).