I like the icons, the karma bubble fix, and the meetup section.
The new layout and colors are neutral to me - neither better nor worse than the old ones.
I'm not sure how I feel about the lime green border to highlight new comments. It's slightly useful, but mildly ugly.
I'll miss the map-territory header. I'm not sure what the new one is supposed to be. It does look better, though.
Not being able to see the number of comments on the main and discussion pages is annoying, even if aesthetically pleasing.
The new retraction mechanic is silly. I wish deletion was back.
I saw some discussion posts earlier talking about a LessWrong redesign, and now that things look different, I guess that it's been implemented. I'm always slightly annoyed for a while when a site I use gets redesigned because I have to relearn where everything is, but it eventually wears off once I'm used to the changes.
My initial impressions:
"Hmmm... it seems like the category menus have been replaced by dropdown menus. It's not like I used many of them anyway."
"Okay, I've clicked my name to see my recently posted comments. Now, where's the link to see it in context? Oh, I guess I have to click that icon in the lower right corner. For some reason I was looking for something at the upper right of the comment box."
"Well, that worked. Now how do I click to the parent comment? Oh, wait, it's probably one of those new icons in the lower right corner. I'll just mouseover them to see what they do..."
::realization sets in::
"AAUGH! LESSWRONG IS USING MYSTERY MEAT NAVIGATION!!!"
So, what does everyone else think of the new redesign?