For example do you think there is negligible chance that genetic engineering or pharmaceuticals could significantly improve human intelligence before machine intelligence gets very far off the ground?

Germ-line genetic engineering is almost totally impotent - since it is too slow. Gene therapy is potentially faster - but faces considerably more technical challenges. It is also irrelevant, I figure.

Pharmaceuticals might increase alertness or stamina, but their effects on productivity seem likely to be relatively minor. People have been waiting for a pharmaceutical revolution since the 1960s. We already have many of the most important drugs, it is mostly a case of figuring out how best to intelligently deploy them.

The main player on the intelligence augmentation front that doesn't involve machines very much is education - where there is lots of potential. Again, this is not really competition for machine intelligence. We have education now. It would make little sense to ask if it will be "first".