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tenshiko comments on Ego syntonic thoughts and values - Less Wrong
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Possibly you'd take a good selection of people whom health professionals have proposed may be suffering from bipolar disorder, and randomly select for patients to either be treated for bipolar disorder, or for doctors to pursue an alternate explanation for the victim's symptoms (such as regular depression or attention deficit disorder - the latter of which has been proposed to be responsible for the vast majority of "bipolar disorder cases" in children). Although this is a pretty sketchy concept. The alternative is for the other group to not be treated at all, but the ethics thereof are even more questionable.
I take offense to "having control groups is unethical".
Moreover, by "not treated at all" you merely mean "not treated with specialized medication for bipolar disorder". Throwing lots of stuff (talk therapy, catch-all medication, support groups, random tricks and environment changes) at the problem until one sticks can work. I'm also rather skeptical of professionals - they have experience, sometimes permission to prescribe stuff, but they don't seem to be all that awesomer than, say, a specialized IRC channel.