Nick_Beckstead comments on Why We Can't Take Expected Value Estimates Literally (Even When They're Unbiased) - Less Wrong
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On a more positive note, Holden and Dario's research on this issue gave me a much better understanding about how the regression would work and how it could suggest that GWWC should be putting more emphasis on evaluating individual charities, relative to relying on (appropriately adjusted) cost-effectiveness estimates.