If nothing else, historical examples show that huge amounts of money lobbed at a cause can go to waste or do more harm than good (e.g. the Iraq war as a means to improve relations with the middle East).

Eliezer and I were both speaking in vague terms; presumably somebody intelligent, knowledgeable, sophisticated, motivated, energetic & socially/politically astute can levy money toward some positive expected change in a given direction. There remains the question about the conversion factor between money and other goods and how quickly it changes at the margin; it could be negligible in a given instance.

The main limiting factor that I had in mind was human capital: an absence of people who are sufficiently intelligent, knowledgeable, sophisticated, motivated, energetic & socially/politically astute.

I would add that a group of such people would have substantially better than average odds of attracting sufficient funding from some philanthropist; further diminishing the value of donations (on account of fungibility).