I've tried a recent version of Sente, and it does a really nice job of streamlining the process of importing PDFs into bib entries, but it's still a manual, one-by-one process. I was very happy to get through about 50 unsorted papers in, I'd say, a quarter hour. For my needs that may be sufficient.

Have you found anything able to digest your 80K papers?

Did you try Papers? It has good reviews, a new 2.0 version, an iPad companion app. Supposedly has metadata import now.

Interesting, I'll give it a try.

ETA: now that I see it, I remember trying it back when I was still using Firefox. Have you been using the new standalone version? It's possible that this will be an improvement over the FF version - I switched to Chrome a while back finding FF just too damn slow and resource-hogging.