The Revolutionary War angle is interesting, but I think it's hard to figure out the implications of that huge a counterfactual.
That is true; but if one really is agnostic, doesn't that argue against the Revolution, and actually strongly against it? You shouldn't kill and wound 100,000 people (Wikipedia's military count alone) and cause the self-exile of >62,000 refugees for something you don't know to even be a net benefit!
Latest in an irregular series, some of whose previous entries were Edge.org and the Girl Scouts...
I examine the Folding@home distributed computing project with reference to the costs (electricity resulting in air pollution causing deaths) and benefits (some papers): http://www.gwern.net/Charity is not about helping. Additional data on either side of the cost-benefit is welcome.
(I also recently split out my essay describing things I have changed my mind on.)