gwern comments on Case study: Folding@home - Less Wrong
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Folding has already incurred somewhere around $100m in total expenses. Do the Bayesian update on a 1/10th chance not happening... It's not epsilon or zero, I'll tell you that!
Let me ask you something. I know what evidence would convince me that Folding was a good idea: show me a drug based on Folding results or a therapy change or something like that. But is there any evidence that could convince you that Folding is not a good idea? Because everything you've said seems like it could apply to any project.