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dlthomas comments on Rationality Drugs - Less Wrong
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Maybe inclusive genetic fitness is not my utility function.
Same here. As a childfree human, maximizing the number of copies of my DNA is right up there with paperclip maximization on my list of priorities. :-)
One other categories of exceptions: We aren't in the EEA anymore. In particular, we have much looser constraints on available calories than in the EEA, and that changes the optimal settings even for reproductive success.