I think I agree with you about Daniel Boone in space, that if the (personal) resource costs were more tolerable we'd start seeing it. What I'm missing originally is the number of people willing to pay even millions of dollars to simply skim the surface of our atmosphere, a healthy portion of which don't seem primarily motivated by status. So yes, you're coorect that we'd probably have had a lunar colony if it were feasible to deliver people at fairly low cost; in fact, if the cost is low enough, I can see this as highly likely both for Daniel Boones and high risk research.
It would not so much matter if an accident released a virus into the lunar vacuum or obliterated several square miles of lunar surface, but we might have found it useful to station researchers or at least maintenance there to carry this out without communications lag or other issues.
SIAI benefactor and VC Peter Thiel has an excellent article at National Review about the stagnating progress of science and technology, which he attributes to poorly-grounded political opposition, widespread scientific illiteracy, and overspecialized, insular scientific fields. He warns that this stagnation will undermine the growth that past policies have relied on.
Noteworthy excerpts (bold added by me):
In relation to concerns expressed here about evaluating scientific field soundness:
Grave indictors:
HT: MarginalRevolution