I'm skeptical too about the fooming of human beings, for 4 reasons.

1 - There is a simple mechanical inibition in the mass and inner working of the brain, a limit that (I believe) its plasticity isn't able to sustain over an exponential increase in information processing power and storage.

2 - There's the cost of finding optimal strategies for every level and circumstances: it too grows exponentially and the calculations need to be done all over again as soon as a parameter change. This is too much work to sustain in a pre-Singularity lifetime.

3 - There's the fact that our psychic history is deterministically unfolded: this means that your mind will change in the direction that you want if and only if you come in contact with the right mental hack (that is, right for your specific brain).

4 - Last but not least, a maximally efficient life is extremely boring! In this sense, the purpose of life should be to experience the maximally efficient fun, not the maximally efficiency.

I think that the solution of human fooming is an old timer: let the robots and the IA do what they do best, be efficient and relieve us from working. From this POV, the maximally efficient fun thing to do is the Friendly AI (go figure!)