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Jayson_Virissimo comments on Transhumanism and Gender Relations - Less Wrong
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Step 2: Give the tour guide a second shot of testosterone (saline),
Step 3: Give the tour guide a third shot of testosterone (estrogen).
Step 4: Compare the results from Step 2 and Step 3 with that of Step 1.
It might also be worth comparing the results with those from other mind altering drugs.