Um...there is quite a bit of information. For instance, one major hurdle was ice crystal formation, which has been overcome - but at the price of toxicity (currently unspecified, but - in my moderately informed guesstimate - likely to be related to protein misfolding and membrane distortion).
We also have quite a bit of knowledge of synaptic structure and physiology. I can make a pretty good guess at some of the problems. There are likely many others (many more problems that I cannot predict), but the ones I can are pretty daunting.
I was unclear, I didn't mean that there's no information, just that there's potentially no information on specific areas that are critical for a meaningful prediction:
Given that both of these types of events are common when developing new technology, attem...
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