So even in something like the Milwaukee protocol there's still ongoing activity in every neuron? So what is different between human neurons and say those of C. elegans? They can survive substantial reductions in temperature with neuronal activity intact. Even bringing them down to liquid nitrogen temperatures leaves a large fraction surviving and that's true if they are cooled slowly or quickly. What am I missing here?
In order, and briefly:
In essence, this tunes down excitatory signals, while tuning up the inhibitory signals. It doesn't actually stop either, and it certainly doesn't interfere with the signalling process...
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