Does it matter? Your genes and memes basically are who you are. They contain most of the necessary information to make you you, you can not exist without the information describing you existing (however hidden or unavailable it may be to any particular mind) as well!
Freedom in any reasonable sense is the ability to make the future universe will end up in states that you find desirable. Altering the fitness landscape or letting it stay just as it is are both valid courses of action to this goal, though the latter is very unlikely to be the wise choice for us. Hacking your mind to fool your memes to help spread your genes, or vice versa are also merely a tactic in this goal. Replacing your genes and memes with ones that you are supremley confident will do the job of making the future universe as you'd like, or changing the envrionment they express themselves in seem to be valid as well.
Does it matter? Your genes and memes basically are who you are. They contain most of the necessary information to make you you
They are two important parts but there is a whole heap of important information stored in the brain that isn't 'memes'. Sentiments, desires, weightings, skills, habits, aversions. They just don't fit in under 'memes' - I mean whole parts of the brain don't even store memes at all.
The jacket text for Keith Stanovich's The Robot's Rebellion sums up the book well:
The book is an excellent introduction to the first stage of Yudkowskian philosophy: We are robots in a mechanistic universe running on a swiss army knife of cognitive modules. But at least we finally noticed we're robots, and we can use the skills of rationality to hop off our habit treadmills and pursue our values instead. These values are complex and often arbitrary, but we can use our reflective capacities to extrapolate our values based on "higher-order" desires, a desire for preference consistency, and other considerations. All this is argued for at length in Stanovich's book. The only thing missing is a discussion of what to do about all this when AI arrives.