The only real way one can escape the dictate of genes, memes and other selected upon replicators is to change their selective environment in such a way that one's current values (or somewhat improved upon values) are favoured. It is a difficult problem we need to engineer ourselves out of, that we barley consider at all.

It doesn't sound like much of an "escape". You are apparently proposing engineering the environment so that the heritable information you favour comes to dominate. Those things would then be new genes or memes.

We could plausibly escape from tyhe world of DNA-genes - via a memetic takeover. However there is not really any escape from genes and memes. Life is always going to depend on some sort of heritable information.