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timtyler comments on Evidence against Calorie Restriction - Less Wrong
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The combination of the example you gave, CR, and the subtitle of the post you link to "The dangers of using one lab animal to study every disease." is 100% bullshit: CR has been studied in a huge number of animals, from worms to primates. I foolishly read a few paragraphs, and it sounds like Mark Mattson simply hasn't read the literature on CR.
Nope: "Mattson is among the leading researchers on the effects of calorie restriction and the brain." - source.