Vladimir_Nesov comments on The ethics of randomized computation in the multiverse - Less Wrong
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You have control over what happens with the computer, and the measure of consequences is immensely greater with the computer, even if very low in both cases.
Why? It seems to me that the reverse might well be true. Measure of random unhappiness inside the computer depends on the number of bits in a brain. Measure of random unhappiness in reality (given that humans already exist) depends on the number of bits in a "diff" between a happy brain and an unhappy one, which is probably smaller.
ETA: this comment is wrong because neurons in reality are macroscopic, so you need a lot of correlated quantum randomness to flip one of them. Please disregard.
I'm assuming that expected value of running the computer is dominated by universe-optimizing AGIs it generates, which would have much better conditions for bootstrapping from a well-defined program in a fully-functional computer than if they have to do it boltzmann brain-style.
Our world already contains many computers that are subject to quantum fluctuations. Some of them even use quantum noise random number generators, so you just need a small glitch to accidentally execute that data, thus creating all the universe-optimizing AGIs you can imagine.
It's still less probable, and still not under your control.