gwern comments on Recent updates to gwern.net (2011) - Less Wrong
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Comments (18)
I don't recall eating dinner before the test either, so that wouldn't be a confound.
You're not comparing like with like here: 4mg is different from a 1mg dose. It's 400% larger, to be specific. If I took 800mg of modafinil rather than 200mg, I think I'd notice that...
There's no reason that the nicotine would not evaporate. There was a lot of surface area (2 cut sides in addition to the substantial permeability of the gum itself), and I kept it out for 3 or 4 weeks, while all the sources I found spoke of substantial evaporation within minutes or hours and patches being useless after around a day - so I was giving myself a safety factor of >20x precisely to avoid this sort of issue.
Given the precautions I took, I think it's much more likely that the placebofying succeeded and my poor predictions were due to other factors: eg. tolerating to the point where 1mg did not produce significant effects (I hope not, since this would imply that my spacing out of gum use has failed and also that my experiment was an effort in measuring a null effect), the use of nicotine each day without any spacing out (see the writeup, I did this to avoid wasting gum since it was use-it-or-lose-it), or just another demonstration of how significant placebo effects can be (wouldn't be the first time!).
That's interesting. I commonly cut nicotine patches and use them over a period of several days. Since the cut patches are no longer in the sealed package (but still have the plastic backing) should I expect the partial patches I use on the later days to be useless?
I'm not really sure. The more official sources seem to have in mind a full use of a patch, which I'd guess involves removing the full backing; people on Longecity discussing cutting up patches seem to think that you can cut up some brands of patches without too much of a problem and there will only be evaporation from the cut edge (but this is still fast enough that you might want to seal the edge somehow or use the cut patches within the week).
You could try removing the backing from some and then, 'several days' later, seeing if they feel the same as the usual ones.