The central point of that review? No, I don't think so. It is apparent from the ongoing rhesus monkey study that the calorie-restricted animals are much healthier and suffer fewer age-related frailties than the ad-libs.
Regarding CR showing up among blue zones or among the world's oldest people, I think the Okinawans are a fine example of mild-moderate CR in practice.
It is very clear from the ongoing rhesus monkey study that the calorie-restricted animals are much healthier and suffer less age-related frailties than the ad-libs.
How do you measure health, and what do you mean by "very clear"? I think there's general agreement that CR makes age-related deaths less likely. The concern is that it might do that by making other forms of death more likely. If I'm less likely to develop diabetes but more likely to fall / injure myself when I fall, I'm looking at a careful cost-benefit analysis, not a "woo les...