Check out figures S5.D and S6 from the SOM. If the relationship is functional (the linear, parabolic, sinusoidal cases on Figure S6), then the R2 calculated from LOESS regression is quite close to this MIC score, and that's not a coincidence. Of course LOESS R2 just dies when it encounters a non-functional relationship.
I was waiting for someone more knowledgeable to post something about this, but it's been a couple days and thought I'd bring it to LW's attention.
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