Methods of Rationality updates - will there be any?

Yes. But not enough to make it feel like the story is moving towards a conclusion.

medical advances

They will be incremental, enough so that very, very few people will notice any practical impact on their lives. Some advances, however, will be accompanied by a great deal of hype. Evidence will emerge that some treatments which we think work now do not in fact work.

signing up for cryonics?

I will continue to believe cryonics is something I would sign up for if I had money to spare, but will also continue to feel too poor to have money to spare.

the future of AGI

This isn't really about AGI, but I expect to be amazed by at least one cool new application of computing that vaguely resembles human intelligence.