All predictions are for 2012.
Homestuck:
Andrew Hussie releases at least one flash lasting longer than 10 minutes: 65%
Karkat, Terezi, John, Dave, Rose and Jade will not be permanently removed from story (Being killed off but returning as a ghost/sprite/whatever doesn't count as being permanently removed; being killed off and spending eternity in a dream-bubble and having no further contribution to the story does): 80%
The hints that Betty Crocker/Her Imperious Condesencion is running post-scratch Desrse will prove to be misdirection on Hussie's part: 20%
Baseball:
The San Francisco Giants will have a winning season. 80%
The Giants will make the postseason (either as NL West Champions or as a Wildcard team): 50%
Pablo Sandoval will hit at least 25 home runs: 80%
Ryan Braun will successfully appeal his suspension: 45%
Albert Pujols will finish the season with a batting average below .300: 65%
Going through expiring predictions reminded me. Just as we did for 2010 and 2011, it's time for LessWrong to make its beliefs pay rent and give hostages to fortune in making predictions for events in 2012 and beyond.
Suggested topics include: Methods of Rationality updates (eg. "will there be any?"), economic benchmarks (price of gold has been an educational one for me this past year), medical advances (but be careful not to be too optimistic!), personal precommitments (signing up for cryonics?), being curmudgeonly about self-improvement, making daring predictions about the future of AGI, and so on.
As before, please be fairly specific. I intend to put most predictions on PredictionBook.com and it'd be nice if they weren't too hard to judge in the future.
(If you want advice on making good predictions, I've tried to write up a few useful heuristics I've learned. So far in the judging process, I've done pretty well this year, although I'm a little annoyed I got a Yemen prediction right but for the wrong reasons.)