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Nymogenous comments on [LINK] Antidepressants: Bad Drugs... Or Bad Patients? - Less Wrong
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This is especially true for antidepressants because some are only effective on more severe cases (eg Zoloft); self-selection will yield a body of faux-depressed and mildly depressed people on whom the drug has no result.
EDIT: Apparently I was thinking of a different drug.
Zoloft has actually been found to be one of the better drugs for cases of mild chronic depression ("dysthymia").