MixedNuts comments on Quantified Health Prize Deadline Extended - Less Wrong
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It does not seem vanishingly improbable to me. Any organism that must eat complex foodstuffs (which includes all animals big enough to see) must deal with the fact that they have no way to obtain precisely the right quantity and proportions of everything that they need. Their bodies therefore need to be robust to wide variations in their dietary content, resulting in a plateau, possibly a very wide one, between deficits and excesses that do measurable harm. If this is so, then there is no such thing as the exactly optimal amount of a nutrient. Instead, there is a broad range, and if you manage to hit that barn door it doesn't matter where.
Moreover, the organism can afford to require precise balance between nutrients foobar and bazqux if they are nearly always found in the same proportions in its food. When you start supplementing foobar but not bazqux, you won't like the results. And you'll need a lot of knowledge to take into account all such interactions.
Right, that's what's being called for. A lot of knowledge.
That sounds plausible. Any specific real-world examples?
I am not a nutritionist, but I once read in The Economist that something like that was going on between omega-6 and omega-3, and between short- and long-chain omega-3.