GiveWell itself (it directs multiple dollars to its top charities on the dollar invested, as far as I can see, and powers the growth of an effective philanthropy movement with broader implications).
There's an issue of room for more funding.
Some research in the model of Poverty Action Lab.
What information do we have from Poverty Action Lab that we wouldn't have otherwise? (This is not intended as a rhetorical question; I don't know much about what Poverty Action Lab has done).
A portfolio of somewhat outre endeavours like Paul Romer's Charter Cities.
Even in the face of the possibility of such endeavors systematically doing more harm than good due to culture clash?
Political lobbying for AMF-style interventions (Gates cites his lobbying expenditures as among their very best), carefully optimized as expected-value charity rather than tribalism using GiveWell-style empiricism, with the collective action problems of politics offsetting the reduced efficiency and corruption of the government route
Here too maybe there's an issue of room for more funding: if there's room for more funding then why does the Gates Foundation spend money on many other things?
Putting money in a Donor-Advised Fund to await the discovery of more effective charities, or special time-sensitive circumstances demanding funds especially strongly
What would the criterion for using the money be? (If one doesn't have such a criterion then one forever holds off on a better opportunity and this has zero expected value.)
This topic is not really related to the things normally discussed here, but I think it's really important, and it might interest Less Wrongers, especially since many of us are interested in ethics and utility calculations that are essentially cost-benefit analyses. Bone marrow donation in the United States is managed by the National Marrow Donor Program. Because typing donors for matching purposes can be costly, they often require people signing up to donate to pay a registration fee, which probably prevents a lot of people from signing up. These costs are being covered until the end of the month by a corporate sponsor, which means that right now, all you need to do if you live in the US is go to http://marrow.org/Join/Join_Now/Join_Now.aspx and fill out a simple questionnaire. You will be sent a kit to collect a cheek swab, and then you will be entered into the donor database. Doing this does not require you to donate if a match comes up.
The reason I think this might interest Less Wrongers is that this is a really cheap way to improve the world. According to their website, about 1 in 500 potential donors are actually asked to donate, so registering doesn't actually make it all that likely that you will be asked to do anything more. If you ARE a match for someone who needs a donation, the cost to you is at most the temporary pain of marrow extraction (many donors are asked only for blood cells), whereas the other person’s chance to live is much improved. This looks like a huge net positive.
Unfortunately I only found out about this a few days ago, and it only occurred to me today that this might be a forum of people who would respond to the argument "you can make the world better at little cost to yourself." However, I ask that you go to the website and spend a few minutes signing up. This is like buying a 1 in 500 lottery ticket that SAVES SOMEONE’S LIFE. If the Singularity hits and an FAI can generate perfectly matched marrow for anyone who needs it from totipotency-induced cells, that will be wonderful, but this is a chance to make sure one more person gets there.