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GabrielDuquette comments on Rationality Quotes February 2012 - Less Wrong
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Is this true? Naive Googling yields this, which suggests (non-authoritatively) that blood sugar and moods are indeed linked (in diabetics, but it's presumably true in the general population). However, despair is not noted and the effects generally seem milder than that (true despair is a rather powerful emotion!)
Low moods and despair are both made of atoms. The quality of atomness doesn't vanish as bad feelings get worse. The quote is suggesting that keeping this fact in mind may be therapeutically valuable -- you're probably less likely to despair if you understand that your despair has a knowable, physical, potentially correctable basis.