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glenra comments on The Unfinished Mystery of the Shangri-La Diet - Less Wrong
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Also, fat cells are biologically active. Obesity is caused by hormone activity and fat cells provide inputs into that biological process as well as being part of the outcome of it.
Rats that overproduce insulin can die of starvation despite being obese - the body gets energy by breaking down muscle - including heart muscle - in order to preserve the fat.
Source?