Having worked on the Voynich Manuscript (which you namecheck above) for over a decade now, I'd say that uncertainty isn't just a feeling: rather, it's the default (and indeed natural) state of knowledge, whereas certainty is normally a sign that we've somehow failed to grasp and appreciate the limits and nature of our knowledge.

Until you can eradicate the itch that drives you to want to make knowledge final, you can never be properly curious. Real knowledge doesn't do final or the last words on a subject: it's conditional, partial, constrained, and heuristic. I contend that you should train your ape-brain to stay permanently curious: almost all certain knowledge is either fake or tautologous.