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wedrifid comments on Is masochism necessary? - Less Wrong
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I find this claim highly suspicious, because the little bit I know about neurobiology tells me that pain and pleasure are controlled by neurotransmitter chemicals, not by synapse connections (wiring), and so it should not be possible to cross them except by genetic defect.
This does not necessarily follow. The neurotransmitter chemicals can remain the same but whole areas of the brain can be rewired such that the area processing the pain can be connected differently to the rest of the brain, including an area which experiences pleasure.
(This is not an endorsement of the grandparent.)