Would you mind going into details?
I was referring to the difficulty cryonics organizations have had in recruiting customers, and their slow growth. I was contrasting this to the rapid growth of cost-effectiveness oriented efforts in private charity in aid, and the sophistication and money moved of groups like GiveWell (with increasing billionaire support), Giving What We Can, Life You Can Save, etc.
Right now it may seem like there is no cheap route for effective brain preservation, but it is also clear that we as a species have not tried very hard to find out. Do you weigh that uncertainty in your calculations?
Yes, that's responsible for much of the EV in my mind.
One counter to this, which I do not necessarily endorse
I first talked about cryonics not being at the frontier of existential risk reduction, and then separately said that I thought GiveWell type donations would do better for preserving current people than cryonics. I don't think that marginal malaria cures have very large effects on existential risks, and was not making any claim about the sign (I am not very confident either way). I was trying to illustrate that for a variety of disinterested objective functions I was skeptical about cryonics promotion coming out on top, except in terms of the welfare of cryonicists (a motive I can strongly sympathize with).
ETA: I did not include plastination under the banner of cryonics (since it isn't cryonics, in terms of temperature, organizational structure, or technology). It looks more promising from a state of relative ignorance.
He has resumed posting at his blog Chronopause and he is essential reading for those interested in cryonics and, more generally, rational decision-making in an uncertain world.
In response to a comment by a LW user named Alexander, he writes:
(Sidenote: This reminds me of what Luke considers his most difficult day-to-day tasks.)
On a related note, Carl Shulman has said that more widespread cryonics would encourage more long-term thinking, specifically about existential risk. Is it a consensus view that this would be the case?
Every now and then people ask LW what sort of career they should pursue if they want to have a large impact improving the world. If we agree that cryonics would encourage long-term thinking, and that this would be beneficial, then it seems to me that we should push some of these people towards the research and practice of brain preservation. For example, perhaps http://80000hours.org/search?q=cryonics should have some results.