Dmytry recommends replacing driving with bicycling, and various commenters agreed that the safest way to drive is to avoid driving whenever possible. Living in a city with good public transportation is recommended.

I haven't actually studied this, but as someone who basically uses my bike as a car, it doesn't feel that much safer. Most cities don't have comprehensive enough bike paths to allow you to only use the paths, especially if you have a time limit and want to take the most direct route. Intuitively, it seems like bikes sharing roads with cars, which is basically the only option much of time, is more dangerous because of the fragility of bikes compared to cars. (Since I still bike, I guess I'm willing to put up with this risk in exchange for better physical fitness, saving money on public transit, and getting where I have to be faster.)