I disagree with Nornagest: I think the best place to start is at the beginning. They pretty much had me at "fetch modus", I was hooked from then on. A lot of really inspirational things start to happen later on, f.ex. the Flash animation "[S] WV: Ascend", but it might be difficult to comprehend without reading the earlier parts.

I would also advise starting at the beginning because I'm starting to grow dissatisfied with the double-meta-reacharaound tack that the comic is taking now... The earlier chapters had a much more coherent story, IMO.