Try writing an article that says exactly the opposite of something that somebody with very high (>10,000) karma says, even linking to their statement to make the contrast clear. Bonus points if you end up getting into a civil conversation directly with that person in the comments of your article.

I nominate this as the Less Wrong Summer Challenge, for everybody.

(One modification I'd make: it shouldn't necessarily be the exact opposite: precisely reversed intelligence usually is stupidity. But your thesis should be mutually incompatible with any charitable interpretation of the original claim.)