With perfect knowledge there would be no mystery left about the real world. But that is not what "sense of wonder and mystery" refers to. It describes an emotion, not a state of knowledge. There's no reason for it to die.
Nicely said. I'd like to add that perfect knowledge can only be of the knowable. The non-knowable is irreducibly wondrous and mysterious. The ultimate mystery, why there is something rather than nothing, seems unknowable.
Here's the new thread for posting quotes, with the usual rules: