Yeah, I have the GG genotype of rs1801282 (also known as the Pro12Ala variant in the PPARG gene) too, so 23andme tells me that "a diet high in monounsaturated fat is not likely to have beneficial effects on BMI or waist circumference." On the other hand, shortly after adopting a high-fat diet my weight dropped dramatically.
I have GG there too, which threw me for a loop because I'd been going in a paleo direction. I haven't had any dramatic effects, but I haven't been all that consistent except for blending MCT into my morning coffee. Good to hear rs1801282 isn't the last word on high-fat diets.
I stumbled on this project during my research: food4me.org
The complete mapping of the human genome sequence in 2000 introduced the possibility of individualised medicine, including personalised nutrition. During this time the field of “nutrigenomics” emerged, which examines the relationship between food and gene expression. Many were hopeful about the ability to plan diet recommendations based on an individual’s genetic profile.
However, the promise of personalised nutrition has failed to develop as a commercial service, and matching dietary advice to genetic profiles has proven difficult. Some companies offer genetic mapping and health reports, but these services are often based on inaccurate information.
There is a need to comprehensively analyse the opportunities and challenges in the field of personalised nutrition. In addition, the fundamental question remains, “how can we best use our current understanding of food, genes, and physical traits to design healthier diets tailored for each individual?”
To address these concerns, Food4Me has gathered an international group of experts to survey the current knowledge of personalised nutrition, and to explore the application of individualised nutrition advice. The Food4Me project will also investigate consumer attitudes and produce new scientific tools for implementation.