From reading Taubes and noting various failures of cholesterol-modifying drugs, I'm pretty skeptical about anything to do with cholesterol (in the absence of long-term RCTs showing positive effects on total mortality), so I'll ignore that.

Is this because cholesterol may not be as relevant to health as some believed? Or because the drugs (statins) just don't seem to improve total mortality much (for either the same or a different reason).

I take at times other substances that can have a significant negative side effect on cholesterol profiles. Should I just not bother trying to influence the cholesterol back towards my normal baseline?

Why is it significant?

If the cholesterol did, in fact, matter it'd be kind of neat to change it a bunch. Same with the increased fat burning.

I didn't think you were a professional athlete or anything like that.

Just an amateur one.

And if you're hoping for endurance to be useful because it correlates with other good things, you're throwing a wrench into the works by taking such a drug, which likely affects only endurance.

I was rather surprised myself when they tested this and found that neurogenesis was also increased from the pharmacological activation of the muscles (including by GW1516) in the same way that actual exercise does.