No, it doesn't. You could argue that there's a renewal of atoms (most notably water), but swapping water atoms doesn't have physical meaning, so… No. Heck, even cut&paste transportation doesn't change substrate.
The "yuck factor" I feel cause me to doubt this: If an EM of me would be created during my sleep, what probability would I assign to wake up as silicon, or as wetware? I'm totally not sure I can say 1/2.
Actually it's more complicated than that. Not just water atoms; over time your genetic pattern changes -- the composition of cancerous to non-cancerous cells; the composition of senescent to non-senescent cells; the physical structures of the brain itself change.
Neurogenesis does occur in adults -- so not even on a cellular level is your brain the same today as it was yesterday.
Furthermore -- what makes you confident you are not already in a Matrix? I have no such belief, myself. Too implausible to believe we are in the parent of all universes given physics simulations work.
From Being a Realist (even if you believe in God):
My mother, who doesn't call herself a theist (I think she's agnostic), doesn't even accept realism. She doesn't even agree with this:
That's little more than tautologies here. Yet it elicited an impression of being forced to believe. I know because she told me about the totalitarian dangers from such narrow thinking.
I'm happy to have finally found the root cause of our ongoing disagreement, but now, how can I deal with that? It looks pretty hopeless, but just in case, does someone have a suggestion, or should I just leave it at that? (My ego doesn't like it, but giving up is an option.)
Now I'm relieved to know that in near mode, she's a complete realist. This craziness only shows up in far mode.