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mwengler comments on One possible issue with radically increased lifespan - Less Wrong
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The dissonance is between the modifications you would like to see and the modifications which will dominate. Even if 99.999% wants to see a kinder, gentler, less psychopathic human, if there is one a-hole in the bunch who turns up psychopathic agression and reproduction drive in such a way that the resulting creature does pretty well, his result will dominate.
I would bet that personalities that will not kill off the other creatures who are genetically dangerous to them will never, over time, be on the winning side.
Not dominate, but force a mixed strategy; as I pointed out in another comment last week:
In game theory, whether social or evolutionary, a stable outcome usually (I'm tempted to say almost always) includes some level of cheaters/defectors.
Which requires the majority to have some means of dealing with them when they are encountered.