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tgb comments on Rationality Quotes June 2012 - Less Wrong
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In the context of the youtube link where the quote is from, he is saying what he learned from working under Thurgood Marshall - a man who probably did change the world.
Furthermore, what he is saying seems trivially true; the thing you need to know to change the world is how to get the change that you want. Knowing which things you need to know doesn't imply that you know those things!