My first tought was poop-out, but that doesn't happen with bupropion, only with SSRIs, right? You shouldn't stop and start again the same antidepressant (and, to a lesser extent, antidepressants in the same family, or that target the same neurotransmitter), this will build resistance. With SSRIs, poop-out tends to be resistance at any dose, not tolerance. I've had poop-out from placebo (WTF?) and larger doses don't work there either. A week is a bit short for a test, but bupropion is unusually fast so that's a decent test. Why are you trying to correct for the placebo effect at all? Improvement from placebo is real and desirable, and there's probably a feedback loop between placebo- and drug-related improvement that helps even further. How many antidepressants have you tried? You might just be on the wrong one. How large is your dose? If you're at 300mg/day trying going up to 450 is possible, though I'm not very optimistic. Does your depression have a seasonal pattern at all, and if so could the weather be responsible for the mood drop? You seem oddly trusting in self-experiment and advice from strangers; why are you seeking recommendations besides your psychiatrist's? Cost? Disclaimer: I'm a nutjob who reads Crazy Meds and Neuroskeptic, not a psychiatrist.