I was describing instrumentalism in my comment, and so far it has been working well for me in other areas as well. In mathematics, I would avoid arguing whether a theorem that is unprovable in a certain framework is true or false. In condensed matter physics, I would avoid arguing whether pseudo-particles, such as holes and phonons, are "real". In general, when people talk about a "description of reality" they implicitly assume the map-territory model, without admitting that it is only a (convenient and useful) model. It is possible to talk about observable phenomena without using this model. Specifically, one can describe research in natural science as building a hierarchy of models, each more powerful than the one before, without mentioning the world "reality" even once. In this approach all models of the same power (known in QM as interpretations) are equivalent.
In response to falenas108's "Ask an X" thread. I have a PhD in experimental particle physics; I'm currently working as a postdoc at the University of Cincinnati. Ask me anything, as the saying goes.
This is an experiment. There's nothing I like better than talking about what I do; but I usually find that even quite well-informed people don't know enough to ask questions sufficiently specific that I can answer any better than the next guy. What goes through most people's heads when they hear "particle physics" is, judging by experience, string theory. Well, I dunno nuffin' about string theory - at least not any more than the average layman who has read Brian Greene's book. (Admittedly, neither do string theorists.) I'm equally ignorant about quantum gravity, dark energy, quantum computing, and the Higgs boson - in other words, the big theory stuff that shows up in popular-science articles. For that sort of thing you want a theorist, and not just any theorist at that, but one who works specifically on that problem. On the other hand I'm reasonably well informed about production, decay, and mixing of the charm quark and charmed mesons, but who has heard of that? (Well, now you have.) I know a little about CP violation, a bit about detectors, something about reconstructing and simulating events, a fair amount about how we extract signal from background, and quite a lot about fitting distributions in multiple dimensions.