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RobertLumley comments on Neuroscience basics for LessWrongians - Less Wrong
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Yeah, I will definitely concede small ones have negligible costs. And I'm not sure the answer to 1) is known, and I doubt 2) is well quantified. A good rule of thumb for 2) though is that "if you're asking whether or not it's possible, it probably is". At least that's the rule of thumb I've developed from asking questions in classes.