Ugly as HELL [1]. I have not actually read any of the text, I will simply list elements I dislike, in the order I saw them. My opinion matters little, I suggest you get some critique from Hacker News [2].

• logo does not stand out

• grey buttons have a weird volume, I think the white border causes this

• RSS logo stands out more than SI logo, I have not seen RSS logos used to denote a blog in years

• text in search box has a weird white glow, glass effect is ugly, magnifying glass icon is aliased, it changing to orange on hover makes it look like you just learned about complementary colors.

• text in slideshow is aliased (Win7, Chrome latest)

• grey android thing in second slideshow panel is creepy

• big light blue clipart-thingies look childish

• font on http://singularity.org/what-we-do/ is weird, the letter c looks like e

• meaningless math symbols in the background make me cringe

My impressions the moment I saw the main page: old, cheap, childish, scammy. I would prefer clean, if not minimalist.

[1] http://helldesign.net/ everything they do is ugly, their own website included

[2] http://news.ycombinator.com/ they won't like it