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gwern comments on Empirical Sleep Time - Less Wrong
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Que? If I'm randomizing week-blocks and I'm measuring my sleep data each night, and I have 7*4 nights on and 7*4 nights off, don't I have as many datapoints as if I randomized 56 individual nights on and off? I'm not testing solely at the beginning or end of each block. Even if it takes a full 6 days to reach steady-state, I still get signal from day 7.
The data doesn't become representative of what you're trying to test (long term use), until after it's stabilized or tolerance is developed.
For example, imagine you're testing a stimulant which keeps you from sleeping the first few days, but eventually helps you focus better and sleep normal. You can't use the sleep deprived data from the beginning of the cycle if your goal is to identify the effects of using it long term.
I guess it's obvious, but I was just pointing out that it takes longer to do a self experiment on something that has effects which change gradually over time vs something that can be assumed to stabilize quickly.